Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice.

Kasai K, Igarashi N, Tada Y, Kani K, Takano S, Yanagibashi T, Usui-Kawanishi F, Fujisaka S, Watanabe S, Ichimura-Shimazu M, Takatsu K, Tobe K, Tsuneyama K, Furusawa Y,  Ngagai Y.

Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis.

Tada Y, Kasai K, Makiuchi N, Igarashi N, Kani K, Takano S, Honda H, Yanagibashi T, Watanabe Y, Usui-Kawanishi F, Furusawa Y, Ichimura-Shimazu M, Tabuchi Y, Takatsu K, Tsuneyama K, Ngagai Y. 

Int J Mol Sci. 2022 Nov; 23(21):13251.  doi: 10.3390/ijms232113251.

Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.

Watanabe S, Usui-Kawanishi F, Karasawa T, Kimura H, Kamata R, Komada T, Inoue Y, Mise N, Kasahara T, Takahashi M.

J Cell Physiol. 2020 Mar 1. doi: 10.1002/jcp.29659.

ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome.

Watanabe S, Usui-Kawanishi F, Komada T, Karasawa T, Kamata R, Yamada N, Kimura H, Dezaki K, Ohmori T,  Takahashi M.

Biochem Biophys Res Commun. 2020 Oct 15;531(2):125-132. doi: 10.1016/j.bbrc.2020.07.063.  

Implications of Immune-Inflammatory Responses in Smooth Muscle Dysfunction and Disease. 

Usui-Kawanishi F, Takahashi M, Sakai H, Suto W, Kai Y, Chiba Y, Hiraishi K, Kurahara LH, Hori M, Inoue R. 

 J Smooth Muscle Res. 2019;55(0):81-107. doi: 10.1540/jsmr.55.81.

Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease. 

Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, Ohno N, Kasahara T, Minota S, Takahashi M. 

Sci Rep. 2018 May 15;8(1):7601. doi: 10.1038/s41598-018-25856-0.

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages. 

Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R, Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama N, Shimano H, Kasahara T, Takahashi M.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):744-756. doi: 10.1161/ATVBAHA.117.310581.

ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.

Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.

J Immunol. 2017 Nov 15;199(10):3614-3622. doi: 10.4049/jimmunol.1700184.

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction.

Kobayashi M, Usui-Kawanishi F, Karasawa T, Kimura H, Watanabe S, Mise N, Kayama F, Kasahara T, Hasebe N, Takahashi M.

PLoS One. 2017 May 11;12(5):e0176676. doi: 10.1371/journal.pone.0176676.